Jayakumar R, Nwe N, Tokura S, Tamura H
Biofunctionalization Laboratory, Faculty of Engineering and HRC, Kansai University, Osaka 564-8680, Japan.
Int J Biol Macromol. 2007 Feb 20;40(3):175-81. doi: 10.1016/j.ijbiomac.2006.06.021. Epub 2006 Jul 1.
Chitin and chitosan are known to be natural polymers and they are non-toxic, biodegradable and biocompatible. Chemical modification of chitin and chitosan with sulfate to generate new bifunctional materials is of interest because the modification would not change the fundamental skeleton of chitin and chitosan, would keep the original physicochemical and biochemical properties and finally would bring new or improved properties. The sulfated chitin and chitosan have a variety of applications, such as, adsorbing metal ions, drug delivery systems, blood compatibility, and antibacterial field. The purpose of this review is to take a closer look about the different synthetic methods and potential applications of sulfated chitin and chitosan. Based on current research and existing products, some new and futuristic approaches in this context area are discussed in detail. From the studies reviewed, we concluded that sulfated chitin and chitosan are promising materials for biomedical applications.
甲壳素和壳聚糖是已知的天然聚合物，它们无毒、可生物降解且具有生物相容性。用硫酸盐对甲壳素和壳聚糖进行化学改性以生成新的双功能材料备受关注，因为这种改性不会改变甲壳素和壳聚糖的基本骨架，能保持其原有的物理化学和生物化学性质，最终还会带来新的或改进的性能。硫酸化甲壳素和壳聚糖有多种应用，例如吸附金属离子、药物递送系统、血液相容性以及抗菌领域。本综述的目的是更深入地了解硫酸化甲壳素和壳聚糖的不同合成方法及潜在应用。基于当前的研究和现有产品，详细讨论了该领域一些新的和未来的方法。从所综述的研究中，我们得出结论：硫酸化甲壳素和壳聚糖是用于生物医学应用的有前景的材料。
