Hughes R A, Rees J H
Department of Neurology, United Medical and Dental School, Guy's Hospital, London, United Kingdom.
J Infect Dis. 1997 Dec;176 Suppl 2:S92-8. doi: 10.1086/513793.
Guillain-Barré syndrome (GBS) is defined clinically as a peripheral neuropathy causing limb weakness that progresses for up to 4 weeks before reaching a plateau. The symptoms may be caused by inflammatory demyelination, axonal degeneration, or both. GBS occurs throughout the world, with a median incidence of 1.3 cases/100,000 population (range, 0.4-4.0). Males are more commonly affected than females, and there are peaks in young adults and the elderly. There is no clear seasonal association in Western countries, although this may be because the most frequent antecedent events, respiratory and enteric infections, have opposite seasonality. The most frequently identified cause of GBS is Campylobacter jejuni infection, which has been identified in up to 41% of patients and is associated with more severe disease and prolonged disability. Summer epidemics of GBS occur among children and young adults in Northern China and are particularly likely to be associated with C. jejuni infection.
吉兰-巴雷综合征（GBS）在临床上被定义为一种导致肢体无力的周围神经病变，在达到平台期之前会进展长达4周。症状可能由炎症性脱髓鞘、轴索性变性或两者共同引起。GBS在世界各地均有发生，发病率中位数为1.3例/10万人口（范围为0.4 - 4.0）。男性比女性更易受影响，在年轻人和老年人中存在发病高峰。在西方国家，虽然这可能是因为最常见的前驱事件——呼吸道和肠道感染具有相反的季节性，但并没有明确的季节性关联。GBS最常见的病因是空肠弯曲菌感染，在高达41%的患者中被发现，且与更严重的疾病和长期残疾有关。在中国北方，GBS的夏季流行发生在儿童和年轻人中，尤其可能与空肠弯曲菌感染有关。
