Plenge P
Int Pharmacopsychiatry. 1976;11(2):84-92. doi: 10.1159/000468216.
Administration of LiCl to rats was found to affect brain glucose metabolism in the following ways. The concentrations of brain glucose, brain lactate and brain glycogen were increased, and the concentration of brain glutamate was decreased. The incorporation of (14)C from U-(14)C D-glucose, administered intraperitoneally to the rats, was increased in brain glucose and brain lactate, and decreased in brain glutamate. The results were explained by a lithium-induced increase in brain glucose uptake and an increased rate of glycolysis, and a slight inhibition of the oxidative decarboxylation of the Krebs cycle.
研究发现，给大鼠注射氯化锂会通过以下方式影响大脑葡萄糖代谢。大脑葡萄糖、大脑乳酸和大脑糖原的浓度增加，而大脑谷氨酸的浓度降低。向大鼠腹腔注射U-(14)C-D-葡萄糖后，大脑葡萄糖和大脑乳酸中(14)C的掺入增加，而大脑谷氨酸中的掺入减少。这些结果的解释是，锂诱导大脑葡萄糖摄取增加、糖酵解速率加快，以及对三羧酸循环的氧化脱羧有轻微抑制作用。
