刺蒺藜果实中的甾体皂苷。

Steroidal saponins from fruits of Tribulus terrestris.

作者信息

Yan W, Ohtani K, Kasai R, Yamasaki K

机构信息

Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.

出版信息

Phytochemistry. 1996 Jul;42(5):1417-22. doi: 10.1016/0031-9422(96)00131-8.

DOI:10.1016/0031-9422(96)00131-8

PMID:9397208

Abstract

Further studies on the constituents of the fruits of Tribulus terrestris led to the isolation of five new steroidal saponins (terrestrosin A-E), (25R,S)-5 alpha-spirostan-3 beta-ol-3 -O-beta-D-galactopyranosyl(1-2)-beta-D- glucopyranosyl(1-4)-beta-D-galactopyranoside, (25R,S)-5 alpha-spirostan-3 beta-ol-3-O-beta-D-glucopyranosyl(1-4)-[alpha-L- rhamnopyranosyl(1-2)]-beta-D-galactopyranoside, (25R,S)-5 alpha-spirostan-12-on-3 beta-ol-3-O-beta-D-galactopyranosyl (1-2)-beta-D-glucopyranosyl(1-4)-beta-D-galactopyranoside, hecogenin 3-O-beta-D-galactopyranosyl)1-2)-[beta-D- xylopyranosyl(1-3)]-beta-D-glucopyranosyl(1-4)-beta-D-galactopyranoside and (25R,S)-5 alpha-spirostane-2 alpha, 3 beta-diol-3- O-beta-D-galactopyranosyl(1-2)-beta-D-glucopyranosyl(1-4)-beta-D- galactopyranoside, together with five known steroidal saponins, desgalactotigonin, F-gitonin, desglucolanatigonin, gitonin and tigogenin 3-O-beta-D- xylopyranosyl)1-2)-[beta-D-xylopyranosyl)1-3)]-beta-D-glucopyranosyl)1-4 )- [alpha-L-rhamnopyranosyl(1-2)]-beta-D-galactopyranoside. The structures of the new saponins were elucidated on the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions.

摘要

对刺蒺藜果实成分的进一步研究导致分离出五种新的甾体皂苷（刺蒺藜素A - E），即(25R,S)-5α-螺甾烷-3β-醇-3 - O-β-D-吡喃半乳糖基(1-2)-β-D-吡喃葡萄糖基(1-4)-β-D-吡喃半乳糖苷、(25R,S)-5α-螺甾烷-3β-醇-3 - O-β-D-吡喃葡萄糖基(1-4)-[α-L-鼠李吡喃糖基(1-2)]-β-D-吡喃半乳糖苷、(25R,S)-5α-螺甾烷-12-酮-3β-醇-3 - O-β-D-吡喃半乳糖基(1-2)-β-D-吡喃葡萄糖基(1-4)-β-D-吡喃半乳糖苷、海柯皂苷元3 - O-β-D-吡喃半乳糖基(1-2)-[β-D-吡喃木糖基(1-3)]-β-D-吡喃葡萄糖基(1-4)-β-D-吡喃半乳糖苷以及(25R,S)-5α-螺甾烷-2α,3β-二醇-3 - O-β-D-吡喃半乳糖基(1-2)-β-D-吡喃葡萄糖基(1-至4)-β-D-吡喃半乳糖苷，同时还分离出五种已知的甾体皂苷，即去半乳糖替告皂苷元、F-吉托皂苷元、去葡萄糖拉那替告皂苷元、吉托皂苷元和替告皂苷元3 - O-β-D-吡喃木糖基(1-2)-[β-D-吡喃木糖基(1-3)]-β-D-吡喃葡萄糖基(1-4)-[α-L-鼠李吡喃糖基(1-2)]-β-D-吡喃半乳糖苷。新皂苷的结构通过光谱分析（包括二维核磁共振技术）和化学反应得以阐明。