Golding J F, Stott J R
Division of Psychology, University of Westminster, London, U.K.
J Vestib Res. 1997 Nov-Dec;7(6):421-8.
The aim of this study was to determine whether the time course of recovery of tolerance, as assessed objectively by rechallenge with motion, paralleled the subjective recovery from motion sickness. Subjects (n = 20) were exposed to 5 pairs of nauseogenic motion challenges in which the time interval between the end of the first and the start of the second of each pair ranged from 15 min to 2 h. The cross-coupled motion challenge had an incrementing profile of rotational velocity from 4 degrees to 92 degrees.s-1 in steps of 4 degrees.s-1 every 30 s, with 8 head movements per 30 s, of approximately 45 degrees, and was continued to the point of moderate nausea. Objective loss of tolerance decreased from 15 min to 60 min after the first challenge, but increased again at 2 h. By contrast, most individuals reported subjective recovery by 15 min to 30 min. It was concluded that there is an underlying effect of motion sickness that sensitizes the response to subsequent motion for a period of at least 2 h. This underlying objective effect can occur in the absence of subjective symptoms, has a slower time course than the subjective recovery from symptoms, and appears to be non-monotonic.
本研究的目的是确定通过运动激发试验客观评估的耐受性恢复时间进程是否与晕动病的主观恢复情况相符。受试者（n = 20）接受了5组致呕性运动激发试验，每组中第一次运动结束至第二次运动开始的时间间隔为15分钟至2小时。交叉耦合运动激发试验的旋转速度呈递增模式，从4度每秒逐步增加到92度每秒，每30秒增加4度每秒，每30秒有8次头部运动，幅度约为45度，持续至中度恶心。第一次激发试验后，客观耐受性丧失从15分钟降至60分钟，但在2小时时再次增加。相比之下，大多数个体报告在15分钟至30分钟时主观恢复。研究得出结论，晕动病存在一种潜在效应，使对后续运动的反应在至少2小时内敏感化。这种潜在的客观效应可在无主观症状的情况下发生，其时间进程比症状的主观恢复慢，且似乎是非单调的。
