Borlongan C V, Cameron D F, Saporta S, Sanberg P R
Department of Surgery, University of South Florida College of Medicine, Tampa 33612, USA.
Exp Neurol. 1997 Nov;148(1):388-92. doi: 10.1006/exnr.1997.6513.
Recently, we demonstrated amelioration of behavioral deficits associated with 6-hydroxydopamine-induced hemiparkinsonism by transplanting rat testis-derived Sertoli cells into adult male rat brains. In the present study, we used adult female hemiparkinsonian rats to investigate whether the beneficial effects of transplantation of Sertoli cells may be differentially affected by gender of the animal transplant recipient. At 1 month posttransplantation, animals transplanted with Sertoli cells showed functional recovery as revealed by significant reductions in apomorphine-induced rotational behavior and asymmetrical elevated body swing behavior. Control animals that received medium alone did not display any visible behavioral recovery. These results suggest that transplantation of Sertoli cells is not male hormone-dependent and further support the use of these cells as a graft source for Parkinson's disease and other neurological disorders.
最近，我们通过将大鼠睾丸来源的支持细胞移植到成年雄性大鼠脑内，证实了与6-羟基多巴胺诱导的偏侧帕金森病相关的行为缺陷得到改善。在本研究中，我们使用成年雌性偏侧帕金森病大鼠来研究支持细胞移植的有益效果是否会因动物移植受体的性别而受到不同影响。移植后1个月，移植了支持细胞的动物表现出功能恢复，这通过阿扑吗啡诱导的旋转行为和不对称性抬高身体摆动行为的显著减少得以体现。仅接受培养基的对照动物未表现出任何明显的行为恢复。这些结果表明，支持细胞的移植不依赖雄性激素，并进一步支持将这些细胞用作帕金森病和其他神经疾病的移植来源。
