恙虫病东方体感染患者血清中巨噬细胞集落刺激因子、γ干扰素和肿瘤坏死因子α水平升高。
Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with Orientia tsutsugamushi infection.
作者信息
Iwasaki H, Takada N, Nakamura T, Ueda T
机构信息
First Department of Internal Medicine, Fukui Medical School, Matsuoka, Japan.
出版信息
J Clin Microbiol. 1997 Dec;35(12):3320-2. doi: 10.1128/jcm.35.12.3320-3322.1997.
Abstract
Levels of macrophage colony-stimulating factor (nine of nine patients) and gamma interferon (six of nine patients) in serum were elevated above the range of normal in the acute phase of tsutsugamushi disease. Significant increases in levels of tumor necrosis factor alpha were observed during the convalescent phase in five patients, and they exceeded the levels observed during the acute phase. Hypercytokinemia appeared to be responsible for the emergence of the symptoms of tsutsugamushi disease.
摘要
恙虫病急性期，血清中巨噬细胞集落刺激因子水平（9例患者中的9例）和γ干扰素水平（9例患者中的6例）高于正常范围。5例患者在恢复期观察到肿瘤坏死因子α水平显著升高，且超过急性期观察到的水平。高细胞因子血症似乎是恙虫病症状出现的原因。
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