Jacomella V, Sauser A, Truttmann A C, Kuhlmann-Siegenthaler B V, Capillo S, Bianchetti M G
Department of Pediatrics, University of Bern, Inselspital, Switzerland.
Acta Diabetol. 1997 Oct;34(3):235-7. doi: 10.1007/s005920050080.
The recognized existence of a circadian pattern in extracellular magnesium balance might mirror either an inherent rhythm in the homeostasis of this ion or dietary factors. Since in vitro insulin enhances cellular magnesium uptake, the circadian rhythm in extracellular magnesium metabolism might be modulated at least in part by carbohydrate intake. To assess this hypothesis, the effects of oral glucose loading on plasma total and ionized magnesium were investigated in lean healthy humans with a negative family history for essential hypertension and diabetes mellitus. Plasma total and ionized magnesium was similar before glucose loading and 30, 60, 90, 180, and 210 min thereafter. It is therefore concluded that in healthy humans the circadian pattern of extracellular magnesium is not modulated by the metabolic and hormonal mechanisms that adjust the concentration of glucose.
细胞外镁平衡中昼夜节律模式的公认存在，可能反映了该离子体内稳态的固有节律或饮食因素。由于体外胰岛素可增强细胞对镁的摄取，细胞外镁代谢的昼夜节律可能至少部分受碳水化合物摄入量的调节。为了评估这一假设，我们对无原发性高血压和糖尿病家族史的健康瘦人进行了口服葡萄糖负荷试验，以研究其对血浆总镁和离子化镁的影响。葡萄糖负荷前及负荷后30、60、90、180和210分钟时，血浆总镁和离子化镁水平相似。因此得出结论，在健康人体内，调节葡萄糖浓度的代谢和激素机制不会调节细胞外镁的昼夜模式。
