从丝裂霉素C处理的金黄色葡萄球菌V8（ATCC 49775）中分离出的类噬菌体颗粒中的杀白细胞素基因。
Panton-valentine leukocidin genes in a phage-like particle isolated from mitomycin C-treated Staphylococcus aureus V8 (ATCC 49775).
作者信息
Kaneko J, Kimura T, Kawakami Y, Tomita T, Kamio Y
机构信息
Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
出版信息
Biosci Biotechnol Biochem. 1997 Nov;61(11):1960-2. doi: 10.1271/bbb.61.1960.
The staphylococcal Panton-Valentine leukocidin (PVL) genes [lukS-PV-lukF-PV] existed in a hexagonal phage-like particle (phi PVL) isolated from mitomycin C-induced Staphylococcus aureus V8 (ATCC 49775). The genome packed in phi PVL was a linear double-stranded 40-kb DNA with single-stranded cohesive ends (cos). The [lukS-PV-lukS-PV], attP, and int (integrase gene) of phi PVL were all located very close to one another within a 4.0 kb-segment on the genome in the order given, and the segment is located at the center from the left and the right cos sites. In addition, the [lukS-PV-lukF-PV]-attP-int region contains 5 direct repeat sequences that show high similarity with the recombinase-binding sites of bacteriophages of S. aureus.
葡萄球菌杀白细胞素（PVL）基因 [lukS-PV-lukF-PV] 存在于从丝裂霉素 C 诱导的金黄色葡萄球菌 V8（ATCC 49775）中分离出的一种六边形噬菌体样颗粒（phi PVL）中。包装在 phi PVL 中的基因组是一种线性双链 40 kb DNA，具有单链粘性末端（cos）。phi PVL 的 [lukS-PV-lukS-PV]、attP 和 int（整合酶基因）在基因组上的一个 4.0 kb 片段内按给定顺序彼此非常靠近，并且该片段位于左右 cos 位点中心。此外，[lukS-PV-lukF-PV]-attP-int 区域包含 5 个直接重复序列，这些序列与金黄色葡萄球菌噬菌体的重组酶结合位点具有高度相似性。
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