Center for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, University of Greifswald, D-17489 Greifswald, Germany.
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland.
Toxins (Basel). 2019 Jun 11;11(6):332. doi: 10.3390/toxins11060332.
Necrotizing soft tissue infections (NSTIs) are critical clinical conditions characterized by extensive necrosis of any layer of the soft tissue and systemic toxicity. Group A streptococci (GAS) and are two major pathogens associated with monomicrobial NSTIs. In the tissue environment, both Gram-positive bacteria secrete a variety of molecules, including pore-forming exotoxins, superantigens, and proteases with cytolytic and immunomodulatory functions. The present review summarizes the current knowledge about streptococcal and staphylococcal toxins in NSTIs with a special focus on their contribution to disease progression, tissue pathology, and immune evasion strategies.
坏死性软组织感染（NSTIs）是一种严重的临床病症，其特征为任何一层软组织发生广泛坏死和全身中毒。A 组链球菌（GAS）和 是与单微生物 NSTIs 相关的两种主要病原体。在组织环境中，革兰氏阳性菌都会分泌多种分子，包括形成孔的外毒素、超抗原和具有细胞溶解和免疫调节功能的蛋白酶。本综述总结了关于 NSTIs 中链球菌和葡萄球菌毒素的最新知识，特别关注它们对疾病进展、组织病理学和免疫逃避策略的贡献。
