Miyoshi M, Sakurai T, Kodama S
Department of Pediatrics, Himeji Red Cross Hospital.
Arerugi. 1997 Oct;46(10):1036-43.
The reliability of assay methods was studied between LUMIWARD and CAP RAST due to the removal of some kinds of foods and/or challenge test. In the 45 infants with atopic dermatitis, egg, milk, flour, rice, and soybean were removed from foods and/or challenge test of those foods were carried out by every three months as possible. At the same time, the allergen-specific IgE antibodies were measured with LUMIWARD and CAP RAST. The negative concordance rate of LUMIWARD and CAP RAST. The negative concordance rate of LUMIWARD was elevated more than that of CAP RAST and the positive concordance rate of CAP RAST was elevated more than that of LUMIWARD. These results suggests that CAP RAST is useful for the determination of removal of foods, while LUMIWARD is useful for the determination of foods to challenge. The risk of overlooking the allergen exists, because the positive concordance concordance rates of LUMIWARD were low in the milk and flour. With developing age, the negative concordance rates decreased in CAP RAST, therefore unnecessary removal of foods may continue for a long time. The determination of low concentration with LUMIWARD was unreliable.
由于去除了某些种类的食物和/或进行了激发试验，对LUMIWARD和CAP RAST检测方法的可靠性进行了研究。在45例特应性皮炎婴儿中，从食物中去除了鸡蛋、牛奶、面粉、大米和大豆，并且尽可能每三个月对这些食物进行一次激发试验。同时，用LUMIWARD和CAP RAST检测过敏原特异性IgE抗体。LUMIWARD和CAP RAST的阴性一致性率。LUMIWARD的阴性一致性率比CAP RAST升高得更多，而CAP RAST的阳性一致性率比LUMIWARD升高得更多。这些结果表明，CAP RAST有助于确定食物的去除情况，而LUMIWARD有助于确定激发试验的食物。由于LUMIWARD在牛奶和面粉中的阳性一致性率较低，存在漏检过敏原的风险。随着年龄增长，CAP RAST的阴性一致性率下降，因此可能会长期持续不必要地去除食物。用LUMIWARD检测低浓度时不可靠。
