Schmidt L G, Dufeu P, Heinz A, Kuhn S, Rommelspacher H
Department of Psychiatry, Universitätsklinikum Benjamin Franklin, Free University of Berlin, Germany.
Psychiatry Res. 1997 Oct 10;72(3):177-85. doi: 10.1016/s0165-1781(97)00102-9.
The impact of ethanol, cigarette smoking and heroin on serotonin function was evaluated, first in alcoholics during chronic ethanol intoxication and in opiate addicts after long-term heroin consumption, and secondly in both patient groups after detoxification treatment (i.e. a short-term abstinence of 8 days). Our results showed that the 5-hydroxytryptamine (5-HT) content in platelets was: (1) increased in the subgroup of anti-social alcoholics; (2) transiently and differently altered in alcoholics compared to opiate addicts; and (3) lowered in drinking alcoholics and normal in alcoholics who were drinking as well as smoking (that may occur via MAO-B inhibition by smoke). The findings indicate that alterations of the peripheral and possibly the central serotonin system may occur as predisposing factors for alcoholism in individuals with anti-social traits; they may also have some impact on the progression of alcoholism due to its lowered function during chronic ethanol intoxication that is substantially modified by smoking.
评估了乙醇、吸烟和海洛因对血清素功能的影响，首先是在慢性乙醇中毒期间的酗酒者以及长期吸食海洛因后的阿片类成瘾者中进行评估，其次是在两组患者接受解毒治疗后（即短期禁欲8天）进行评估。我们的结果表明，血小板中5-羟色胺（5-HT）的含量：（1）在反社会酗酒者亚组中升高；（2）与阿片类成瘾者相比，酗酒者中5-HT含量短暂且有不同变化；（3）在饮酒的酗酒者中降低，而在既饮酒又吸烟的酗酒者中正常（这可能是通过烟雾对单胺氧化酶B的抑制作用发生的）。这些发现表明，外周以及可能的中枢血清素系统的改变可能是具有反社会特质个体酗酒的诱发因素；它们也可能对酗酒的进展产生一定影响，因为在慢性乙醇中毒期间其功能降低，而吸烟会对这种降低产生实质性改变。
