Poggio Claudio, Arciola Carla Renata, Beltrami Riccardo, Monaco Annachiara, Dagna Alberto, Lombardini Marco, Visai Livia
Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Policlinico "San Matteo", Piazzale Golgi 3, 27100 Pavia, Italy.
Research Unit on Implant Infections, Rizzoli Orthopedic Institute, DIMES of the University of Bologna Via di Barbiano 1/10, 40136 Bologna, Italy.
ScientificWorldJournal. 2014;2014:181945. doi: 10.1155/2014/181945. Epub 2014 May 18.
The aim of this study was to evaluate and compare the antimicrobial activity and cytocompatibility of six different pulp-capping materials: Dycal (Dentsply), Calcicur (Voco), Calcimol LC (Voco), TheraCal LC (Bisco), MTA Angelus (Angelus), and Biodentine (Septodont). To evaluate antimicrobial activity, materials were challenged in vitro with Streptococcus mutans, Streptococcus salivarius, and Streptococcus sanguis in the agar disc diffusion test. Cytocompatibility of the assayed materials towards rat MDPC-23 cells was evaluated at different times by both MTT and apoptosis assays. Results significantly differed among the different materials tested. Both bacterial growth inhibition halos and cytocompatibility performances were significantly different among materials with different composition. MTA-based products showed lower cytotoxicity and valuable antibacterial activity, different from calcium hydroxide-based materials, which exhibited not only higher antibacterial activity but also higher cytotoxicity.
Dycal（登士柏）、Calcicur（沃柯）、Calcimol LC（沃柯）、TheraCal LC（必思科）、MTA Angelus（安杰卢斯）和Biodentine（Septodont）。为了评估抗菌活性，在琼脂平板扩散试验中用变形链球菌、唾液链球菌和血链球菌对材料进行体外挑战。通过MTT和凋亡试验在不同时间评估被测材料对大鼠MDPC - 23细胞的细胞相容性。测试的不同材料之间结果有显著差异。不同组成的材料之间细菌生长抑制晕圈和细胞相容性表现均有显著差异。基于MTA的产品显示出较低的细胞毒性和有价值的抗菌活性，这与基于氢氧化钙的材料不同，后者不仅表现出更高的抗菌活性，还表现出更高的细胞毒性。
