Dewhirst M W, Prosnitz L, Thrall D, Prescott D, Clegg S, Charles C, MacFall J, Rosner G, Samulski T, Gillette E, LaRue S
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
Semin Oncol. 1997 Dec;24(6):616-25.
New studies in hyperthermia at the basic science, engineering, and clinical level have stimulated renewed enthusiasm for re-investigating its potential as an anticancer therapy. This article reviews the salient features of these recent results and points out areas for additional investigation. Highlighting these new results is the publication of several positive phase III trials for thermoradiotherapy compared to radiotherapy alone. Important highlights are the encouraging results using magnetic resonance imaging for noninvasive thermometry. If this technology is successfully implemented with real time power control it will revolutionize the clinical application of hyperthermia.
基础科学、工程学及临床层面关于热疗的新研究激发了人们重新探究其作为抗癌疗法潜力的新热情。本文回顾了这些最新成果的显著特征，并指出了有待进一步研究的领域。多项热放疗与单纯放疗相比的III期阳性试验的发表凸显了这些新成果。重要亮点是使用磁共振成像进行无创温度测量所取得的鼓舞人心的结果。如果这项技术通过实时功率控制得以成功应用，它将彻底改变热疗的临床应用。
