Amichetti M, Romano M, Busana L, Bolner A, Fellin G, Pani G, Tomio L, Valdagni R
Department of Radiation Oncology, St. Chiara Hospital, Trento, Italy.
Radiother Oncol. 1997 Nov;45(2):155-8. doi: 10.1016/s0167-8140(97)00134-5.
Twenty-seven patients with cervical metastases from squamous cell head and neck tumours were treated with hyperfractionated XRT (total dose 69.60-76.80 Gy, 1.2 Gy b.i.d. five times a week) combined with a total of two to six sessions of superficial external HT. Acute local toxicity was mild; as major acute side effects, only one ulceration was recorded. No severe late side effects were observed. Late toxicity was similar to that observed in our previous studies with the combination of heat and radiation. Nodal complete response was observed in 77% of patients, partial response was observed in 15% of patients and no change was observed in 8% of patients. Five-year actuarial nodal control was 64.5 +/- 19% and 5-year actuarial survival was 24 +/- 10%. The treatment of nodal metastases from head and neck tumours with the combination of HT and hyperfractionated XRT is feasible with an acceptable acute and late toxicity profile.
27例头颈部鳞状细胞肿瘤发生颈部转移的患者接受了超分割放疗（总剂量69.60 - 76.80 Gy，每周5次，每次1.2 Gy，每日2次），并联合总共2至6次的浅表外照射热疗。急性局部毒性较轻；作为主要的急性副作用，仅记录到1例溃疡。未观察到严重的晚期副作用。晚期毒性与我们之前关于热疗与放疗联合应用的研究中观察到的情况相似。77%的患者观察到淋巴结完全缓解，15%的患者观察到部分缓解，8%的患者未观察到变化。5年精算淋巴结控制率为64.5±19%，5年精算生存率为24±10%。热疗与超分割放疗联合治疗头颈部肿瘤的淋巴结转移是可行的，急性和晚期毒性情况均可接受。
