De Stefani E, Deneo-Pellegrini H, Mendilaharsu M, Carzoglio J C, Ronco A
Registro Nacional de Cancer, Montevideo, Uruguay.
Cancer Causes Control. 1997 Nov;8(6):913-21. doi: 10.1023/a:1018424614723.
To examine whether dietary fat and cholesterol modifies lung cancer risk, a case-control study was conducted in Uruguay of 426 men diagnosed from 1993 to 1996 with lung cancer, and 419 hospitalized frequency-matched controls. Dietary patterns were assessed using a 64-item food frequency questionnaire, which allowed the calculation of total energy intake. After adjustment for potential confounders through a model which included tobacco smoking, total energy, a term for all vegetables and fruits, and alpha-carotene intake, an increase in risk for total fat intake for all cell types of lung cancer was observed. Adenocarcinoma of the lung was associated strongly with saturated fat intake (odds ratio [OR] = 2.3, 95 percent confidence interval [CI] = 1.2-4.4), whereas small-cell lung cancer was associated with dietary cholesterol (OR = 2.8, CI = 1.1-7.5). These results suggest that the association of saturated fat and cholesterol could be type-specific, but the high correlation existing between dietary lipids precludes any strong statement about this point.
为了研究膳食脂肪和胆固醇是否会改变肺癌风险，在乌拉圭进行了一项病例对照研究，研究对象包括426名在1993年至1996年期间被诊断为肺癌的男性以及419名住院的频率匹配对照者。使用一份包含64个条目的食物频率问卷评估膳食模式，该问卷可用于计算总能量摄入。通过一个包含吸烟、总能量、所有蔬菜和水果的一项指标以及α-胡萝卜素摄入量的模型对潜在混杂因素进行调整后，观察到所有肺癌细胞类型的总脂肪摄入量风险均有所增加。肺腺癌与饱和脂肪摄入量密切相关（优势比[OR]=2.3，95%置信区间[CI]=1.2 - 4.4），而小细胞肺癌与膳食胆固醇有关（OR = 2.8，CI = 1.1 - 7.5）。这些结果表明，饱和脂肪和胆固醇的关联可能具有类型特异性，但膳食脂质之间存在的高度相关性使得无法就此点做出任何强有力的论断。
