De Stefani E, Fontham E T, Chen V, Correa P, Deneo-Pellegrini H, Ronco A, Mendilaharsu M
Registro Nacional de Cancer, Montevideo, Uruguay.
Int J Cancer. 1997 May 29;71(5):760-6. doi: 10.1002/(sici)1097-0215(19970529)71:5<760::aid-ijc12>3.0.co;2-c.
To examine whether fatty-food consumption modifies lung-cancer risk, a case-control study involving 377 patients with lung cancer and 377 controls was conducted in Uruguay. The study was restricted to men. Dietary patterns were assessed in detail using a 64-item food-frequency questionnaire, which allowed the calculation of total energy intake. After adjustment for potential confounders (body-mass index, family history of lung cancer, total energy intake and tobacco smoking), an increase in risk for fatty-food consumption was observed. In particular, fried foods (OR, 1.54; 95% CI, 1.01-2.35), dairy products (OR, 2.85; 95% CI, 1.73-4.69) and desserts (OR, 2.52; 95% CI, 1.54-4.12) were associated with increases in lung-cancer risk and significant dose-response patterns. The association with dairy products was more evident for adenocarcinoma of the lung (OR, 4.18; 95% CI, 1.87-9.36), whereas increased risks for fried-meat and dessert consumption were observed in each cell type. The association with fried-meat consumption was more pronounced for current smokers and for heavy smokers, whereas dairy products and desserts were associated with risk both in current and in past smokers. In conclusion, fat-rich foods and sucrose-rich foods were positively associated with an increased risk of lung cancer. Although the relationship between fat consumption and lung cancer has been reported, the direct association of lung cancer with sucrose-rich foods should be further investigated.
为了研究食用高脂肪食物是否会改变肺癌风险，乌拉圭开展了一项病例对照研究，涉及377例肺癌患者和377名对照者。该研究仅限于男性。使用一份包含64个条目的食物频率问卷详细评估饮食模式，据此可计算总能量摄入。在对潜在混杂因素（体重指数、肺癌家族史、总能量摄入和吸烟情况）进行调整后，发现食用高脂肪食物会增加风险。具体而言，油炸食品（比值比[OR]为1.54；95%置信区间[CI]为1.01 - 2.35）、乳制品（OR为2.85；95% CI为1.73 - 4.69）和甜点（OR为2.52；95% CI为1.54 - 4.12）与肺癌风险增加及显著的剂量反应模式相关。乳制品与肺腺癌的关联更为明显（OR为4.18；95% CI为1.87 - 9.36），而在每种细胞类型中均观察到食用油炸肉类和甜点的风险增加。食用油炸肉类与现吸烟者和重度吸烟者的关联更为显著，而乳制品和甜点在现吸烟者和既往吸烟者中均与风险相关。总之，富含脂肪的食物和富含蔗糖的食物与肺癌风险增加呈正相关。尽管已有关于脂肪摄入与肺癌关系的报道，但肺癌与富含蔗糖食物的直接关联仍需进一步研究。
