Schiavino D, Nucera E, Milani A, Della Corte A M, D'Ambrosio C, Pagliari G, Patriarca G
Department of Internal Medicine and Allergology, Universitá Cattolica S. Cuore, Rome, Italy.
Allergy Asthma Proc. 1997 Nov-Dec;18(6):363-6. doi: 10.2500/108854197778558061.
The nonallergic rhinitis with eosinophilia syndrome (NARES) is a type of chronic rhinitis, characterized by intense (> 20%) eosinophilia of the nasal secretions. In this study, screening for NARES in 81 patients with nonallergic chronic rhinitis was performed using a modified nasal lavage cytometric method. Twenty-one of the 81 investigated individuals (25.9%) showed nasal eosinophilia greater than 20%, therefore being diagnosed as having NARES. No statistical difference in total serum IgE concentration (Prist Pharmacia) was observed between the NARES subjects and those with other forms of chronic rhinitis, confirming the seemingly nonallergic nature of NARES. In 28.6% of these cases the presence of anosmia was detected: in 19.0% of cases with NARES (all subjects complaining of long-lasting symptoms and suffering from anosmia), nasal polyposis coexisted. Our results confirm that nasal lavage cytometry may represent a useful clinical tool in the diagnosis of chronic rhinitis.
嗜酸性粒细胞增多综合征性非变应性鼻炎（NARES）是一种慢性鼻炎，其特征是鼻分泌物中嗜酸性粒细胞显著增多（>20%）。在本研究中，采用改良的鼻腔灌洗细胞计数法对81例非变应性慢性鼻炎患者进行了NARES筛查。81名受调查个体中有21名（25.9%）鼻嗜酸性粒细胞增多超过20%，因此被诊断为患有NARES。在NARES患者和其他形式的慢性鼻炎患者之间，未观察到总血清IgE浓度（普里斯制药公司）的统计学差异，这证实了NARES看似非变应性的性质。在这些病例中，28.6%检测到嗅觉丧失：在19.0%的NARES病例中（所有主诉长期症状且患有嗅觉丧失的患者），并存鼻息肉。我们的结果证实，鼻腔灌洗细胞计数法可能是诊断慢性鼻炎的一种有用的临床工具。
