Cantorna M T, Hayes C E, DeLuca H F
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
J Nutr. 1998 Jan;128(1):68-72. doi: 10.1093/jn/128.1.68.
1,25-Dihydroxycholecalciferol [1,25-(OH)2D3] has been shown to inhibit the progression of experimental autoimmune encephalomyelitis (EAE). Here we tested the possibility that 1, 25-dihydroxycholecalciferol might be therapeutic for another autoimmune disease, arthritis. Two different animal models of arthritis were tested, namely, murine Lyme arthritis and collagen-induced arthritis. Infection of mice with Borrelia burgdorferi (the causative agent of human Lyme arthritis) produced acute arthritic lesions including footpad and ankle swelling. Supplementation with 1,25-dihydroxycholecalciferol of an adequate diet fed to mice infected with B. burgdorferi minimized or prevented these symptoms. Mice immunized with type II collagen also developed arthritis. The symptoms of this disease were also prevented by dietary supplementation with 1,25-dihydroxycholecalciferol. 1, 25-Dihydroxycholecalciferol given to mice with early symptoms of collagen-induced arthritis prevented the progression to severe arthritis compared with untreated controls. These results suggest that 1,25-dihydroxycholecalciferol and/or its analogs may be a valuable treatment approach to this disease.
1,25-二羟胆钙化醇[1,25-(OH)₂D₃]已被证明可抑制实验性自身免疫性脑脊髓炎（EAE）的进展。在此，我们测试了1,25-二羟胆钙化醇可能对另一种自身免疫性疾病——关节炎具有治疗作用的可能性。我们测试了两种不同的关节炎动物模型，即小鼠莱姆关节炎和胶原诱导的关节炎。用伯氏疏螺旋体（人类莱姆关节炎的病原体）感染小鼠会产生急性关节炎病变，包括足垫和踝关节肿胀。给感染伯氏疏螺旋体的小鼠喂食的充足饮食中补充1,25-二羟胆钙化醇可使这些症状减轻或得到预防。用II型胶原免疫的小鼠也会患上关节炎。通过饮食补充1,25-二羟胆钙化醇也可预防这种疾病的症状。与未治疗的对照组相比，给患有胶原诱导性关节炎早期症状的小鼠给予1,25-二羟胆钙化醇可防止病情发展为严重关节炎。这些结果表明，1,25-二羟胆钙化醇和/或其类似物可能是治疗这种疾病的一种有价值的方法。
