Holman R C, Stoll B J, Clarke M J, Glass R I
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Am J Public Health. 1997 Dec;87(12):2026-31. doi: 10.2105/ajph.87.12.2026.
This study examined trends and risk factors for infant mortality associated with necrotizing enterocolitis in the United States.
Necrotizing enterocolitis-associated deaths and infant mortality rates from 1979 through 1992 were determined by means of US multiple cause-of-death and linked birth/infant death data.
Annual necrotizing enterocolitis infant mortality rates decreased from 1979 through 1986 but increased thereafter and were lower during the 3-year period before (1983 through 1985;11.5 per 100,000 live births) the introduction of surfactants than after (1990 through 1992; 12.3 per 100,000). Low-birthweight singleton infants who were Black male, or born to mothers younger than 17 had increased risk for necrotizing enterocolitis-associated death.
As mortality among low-birth weight infants continues to decline and smaller newborns survive early causes of death, necrotizing enterocolitis-associated infant mortality may increase.
本研究调查了美国坏死性小肠结肠炎相关的婴儿死亡率趋势及风险因素。
通过美国多死因及关联的出生/婴儿死亡数据，确定1979年至1992年坏死性小肠结肠炎相关死亡及婴儿死亡率。
1979年至1986年，坏死性小肠结肠炎婴儿年死亡率下降，但此后上升，且在引入表面活性剂前的3年期间（1983年至1985年；每10万例活产中有11.5例）低于引入后（1990年至1992年；每10万例中有12.3例）。黑人男性低体重单胎婴儿，或母亲年龄小于17岁的低体重单胎婴儿，坏死性小肠结肠炎相关死亡风险增加。
随着低体重婴儿死亡率持续下降，更小的新生儿在早期死亡原因中存活下来，坏死性小肠结肠炎相关的婴儿死亡率可能会上升。
