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Multilocus quantitative trait analysis using the multipoint identity-by-descent method.

作者信息

Lewis C M, Kort E N

机构信息

Division of Medical and Molecular Genetics, United Medical and Dental Schools, London, England.

出版信息

Genet Epidemiol. 1997;14(6):839-44. doi: 10.1002/(SICI)1098-2272(1997)14:6<839::AID-GEPI46>3.0.CO;2-O.

DOI:10.1002/(SICI)1098-2272(1997)14:6<839::AID-GEPI46>3.0.CO;2-O
PMID:9433587
Abstract

The multipoint identity-by-descent method (MIM) was extended to test for evidence of quantitative trait loci in two independent genetic regions. This method is a fast and feasible implementation of a multiple-marker, two-region linkage analysis for quantitative traits. It tests for significant evidence of quantitative trait loci (QTL) in neither, one or both genetic regions tested, and could be extended to an arbitrary number of independent genetic regions. A two-stage analysis was used for the nuclear family data from GAW10. Initially, an analysis of the genomic search was carried out using single-region MIM, with sets of six adjacent markers. Chromosomal regions that showed some evidence of linkage were identified and used in a two-region MIM analysis.

摘要

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