Zhang H L, Nagatsu A, Watanabe T, Sakakibara J, Okuyama H
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Chem Pharm Bull (Tokyo). 1997 Dec;45(12):1910-4. doi: 10.1248/cpb.45.1910.
Seven antioxidative serotonin derivatives were isolated from safflower (Carthamus tinctorius L.) oil cake. Their structures were established as N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]ferulamide (1), N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-p-coumaramide (2), N,N'-[2,2'-(5,5'-dihydroxy-4,4'-bi-1H-indol-3,3'-yl)diethyl]- di-p-coumaramide (3), N-[2-[3'-[2-(p-coumaramido)ethyl]-5,5'-dihydroxy- 4,4'-bi-1H-indol-3-yl]ethyl]ferulamide (4), and N,N'-[2,2'-(5,5'-dihydroxy-4,4'-bi-1H-indol-3,3'-yl)diethyl]- diferulamide (5), N-[2-[5-(beta-D-glucosyloxy)-1H-indol-3-yl)ethyl]- p-coumaramide (6), and N-[2-[5-(beta-D-glucosyloxy)-1H-indol-3-yl)ethyl]ferulamide (7). Antioxidative activities of the compounds were measured by the ferric thiocyanate method and the alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) method, and compounds 1-5 were found to have relatively strong antioxidative activity.
从红花（Carthamus tinctorius L.）油饼中分离出七种抗氧化性血清素衍生物。它们的结构被确定为N-[2-(5-羟基-1H-吲哚-3-基)乙基]阿魏酸酰胺（1）、N-[2-(5-羟基-1H-吲哚-3-基)乙基]-对香豆酸酰胺（2）、N,N'-[2,2'-(5,5'-二羟基-4,4'-联-1H-吲哚-3,3'-基)二乙基]-二对香豆酸酰胺（3）、N-[2-[3'-[2-(对香豆酰胺基)乙基]-5,5'-二羟基-4,4'-联-1H-吲哚-3-基]乙基]阿魏酸酰胺（4）、N,N'-[2,2'-(5,5'-二羟基-4,4'-联-1H-吲哚-3,3'-基)二乙基]-二阿魏酸酰胺（5）、N-[2-[5-(β-D-葡萄糖氧基)-1H-吲哚-3-基)乙基]-对香豆酸酰胺（6）和N-[2-[5-(β-D-葡萄糖氧基)-1H-吲哚-3-基)乙基]阿魏酸酰胺（7）。通过硫氰酸铁法和α,α-二苯基-β-苦味酰基肼（DPPH）法测定了这些化合物的抗氧化活性，发现化合物1-5具有较强的抗氧化活性。
