Shikanai-Yasuda M A, Assis C M, Takeda K M, Tamashiro N, Bueno J P
Laboratório de Investigação Médica em Imunologia (LIM 48), Hospital das Clínicas, São Paulo, Brasil.
Mycopathologia. 1997;138(2):65-9. doi: 10.1023/a:1006806615226.
Independent and dependent (C3b/Fc receptors) opsonic adherence ability of monocytes from thirty-three patients with acute or chronic paracoccidioidomycosis and from 13 healthy individuals were studied in the presence of Paracoccidioides brasiliensis (Pb), Paracoccidioides brasiliensis opsonized by patient's serum (PbPS) or normal serum (PbNS), zymosan opsonized by fresh sera from healthy donors (ZyNS) and erythrocytes opsonized by hemolysin (EA). Statistically significant differences concerning the percentage of adhered monocytes to PbPS (number of adhered monocytes/total number of monocytes) were detected between control and chronic (active and inactive) groups. Significant differences in relationship to the mean number of PbPS (number of fungi in monocytes/total number of monocytes) were also observed between control and chronic active mycosis. Present data suggest that patients with chronic disease have more ability in the first step of phagocytic activity, considered as the main effector mechanism to control the dissemination and severity of paracoccidiodomycosis.
研究了33例急性或慢性副球孢子菌病患者及13名健康个体的单核细胞在巴西副球孢子菌（Pb）、患者血清调理的巴西副球孢子菌（PbPS）或正常血清调理的巴西副球孢子菌（PbNS）、健康供体新鲜血清调理的酵母聚糖（ZyNS）以及溶血素调理的红细胞（EA）存在情况下的独立和依赖（C3b/Fc受体）调理吞噬黏附能力。在对照组与慢性（活动期和非活动期）组之间，检测到单核细胞黏附于PbPS的百分比（黏附单核细胞数/单核细胞总数）存在统计学显著差异。在对照组与慢性活动性真菌病之间，还观察到与PbPS的平均数（单核细胞内真菌数/单核细胞总数）相关的显著差异。目前的数据表明，慢性病患者在吞噬活性的第一步具有更强的能力，而吞噬活性被认为是控制副球孢子菌病传播和严重程度的主要效应机制。
