Mota N G, Peraçoli M T, Mendes R P, Gattass C R, Marques S A, Soares A M, Izatto I C, Rezkallah-Iwasso M T
Department of Microbiology and Immunology, IBBMA, UNESP, Rio de Janeiro, Brazil.
J Med Vet Mycol. 1988 Apr;26(2):105-11. doi: 10.1080/02681218880000151.
Seventy untreated paracoccidioidomycosis patients, 15 with the acute or subacute form of the disease and 55 with the chronic form, were compared with two normal control groups of the same age range. Peripheral blood mononuclear cell subsets were defined by monoclonal antibodies directed at total T cells, helper/inducer and suppressor/cytotoxic T cell subpopulations; B cells, cortical thymocytes and monocyte/null cells. Both groups of patients showed an increased number of monocyte/null cells, a low helper/suppressor ratio and a reduced percentage of total T cells and their helper/inducer subsets. In addition patients with the acute form of the disease exhibited high levels of suppressor/cytotoxic T cells and B cells. These findings are of importance in our attempts to understand the pathogenesis of this mycosis and also to evaluate its prognosis in individual patients.
将70例未经治疗的副球孢子菌病患者（15例为急性或亚急性疾病形式，55例为慢性疾病形式）与两个年龄范围相同的正常对照组进行比较。通过针对总T细胞、辅助/诱导性和抑制/细胞毒性T细胞亚群、B细胞、皮质胸腺细胞和单核细胞/空细胞的单克隆抗体来定义外周血单核细胞亚群。两组患者均表现出单核细胞/空细胞数量增加、辅助/抑制比例降低以及总T细胞及其辅助/诱导亚群的百分比降低。此外，患有急性疾病形式的患者表现出高水平的抑制/细胞毒性T细胞和B细胞。这些发现对于我们理解这种真菌病的发病机制以及评估个体患者的预后具有重要意义。
