Ichikawa K, Kitaoka M, Taki M, Takaishi S, Iijima Y, Boriboon M, Akiyama T
Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Planta Med. 1997 Dec;63(6):540-3. doi: 10.1055/s-2006-957759.
Biological evaluation of the extract prepared from the stem wood of Dracaena loureiri, a Thai folkloric medicine called "Chan-daeng", revealed a significant capacity to inhibit [3H]-estradiol binding to the estrogen receptor. During the course of separation, two novel (1 and 2) and two known retrodihydrochalcones (3 and 4), in addition to three known homoisoflavones (5, 6, and 7), were isolated. The structures of compounds 1 and 2 were established by NMR and MS studies by correlating their spectroscopic properties with those of 3 and 4. Each isolate was assessed for its estrogenic activity. Compounds 1 and 6 exhibited activity comparable to that of genistein and daidzein.
对泰国民间药物“Chan-daeng”（龙血树茎木提取物）的生物学评估显示，其具有显著抑制[3H]-雌二醇与雌激素受体结合的能力。在分离过程中，除了三种已知的高异黄酮（5、6和7）外，还分离出了两种新的（1和2）以及两种已知的反式二氢查耳酮（3和4）。通过将化合物1和2的光谱性质与3和4的光谱性质相关联，利用核磁共振（NMR）和质谱（MS）研究确定了它们的结构。对每个分离物的雌激素活性进行了评估。化合物1和6表现出与染料木黄酮和大豆苷元相当的活性。
