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左炔诺孕酮缓释避孕植入剂(诺普兰)的续用率。比利时的一项前瞻性研究。

Continuation rates with a levonorgestrel-releasing contraceptive implant (Norplant). A prospective study in Belgium.

作者信息

Vekemans M, Delvigne A, Paesmans M

机构信息

Department of Gynaecology/Obstetrics, Centre Hospitalier Universitaire Saint-Pierre, Bruxelles, Belgium.

出版信息

Contraception. 1997 Nov;56(5):291-9. doi: 10.1016/s0010-7824(97)00155-8.

Abstract

Contraceptive protection offered by a method depends on its duration of use, which reflects costs, side effects, and relatives' opinions. This study investigated in Norplant implants users the continuation rates, some of their determinants, and the motives for removals. Since 1988, 612 Norplant implants sets, designed to protect for 5 years, have been inserted. Observing 13,907 months of use, we determined over time the continuation rates and how age, parity, circumstances at insertion (postpartum, postabortum, others), and patronymic origins (surrogate for sociocultural factors) influenced them. Statistics included Kaplan-Meier's method and log rank tests, and uni- and multivariate Cox models. Continuation increased with age and depended on sociocultural factors. Parity exerted influence only in younger women. Median duration of use was 3 years 11 months. Removals before 5 years related almost equally to irregular bleeding, other side effects, and pregnancy wish. The cumulative 5-year failure rate was 1.5%. Unsatisfied users returned earlier, distorting the first results. A literature search showed that implants yield, in the mean, slightly better continuation figures than do intrauterine devices, and clearly higher than those obtained with pills and injectables. To optimize costs and counseling, warnings about the risk of short duration of use in young nullipara, especially if negative sociocultural influences prevail, are recommended. In no category are the implants absolutely to be avoided. Individual and programmatic contraceptive choice should take into account the expected continuation of use.

摘要

一种避孕方法所提供的避孕保护取决于其使用时长,而使用时长反映了成本、副作用以及亲属的意见。本研究调查了使用诺普兰皮下埋植剂的使用者的持续使用率、部分决定因素以及取出埋植剂的动机。自1988年以来,共植入了612套设计可提供5年避孕保护的诺普兰皮下埋植剂。通过观察13907个月的使用情况,我们确定了随时间变化的持续使用率,以及年龄、产次、植入时的情况(产后、流产后、其他)和姓氏来源(社会文化因素的替代指标)如何对其产生影响。统计方法包括Kaplan-Meier法和对数秩检验,以及单变量和多变量Cox模型。持续使用率随年龄增长而增加,并取决于社会文化因素。产次仅对年轻女性有影响。使用时间的中位数为3年11个月。5年之前取出埋植剂几乎同样与不规则出血、其他副作用以及生育意愿有关。5年累计失败率为1.5%。不满意的使用者更早取出埋植剂,这扭曲了最初的结果。文献检索表明,平均而言,皮下埋植剂的持续使用数据略优于宫内节育器,且明显高于口服避孕药和注射用避孕药。为了优化成本和咨询服务,并建议对年轻未生育女性使用时间较短的风险发出警告,特别是在负面社会文化影响占主导的情况下。在任何类别中,都不应绝对避免使用皮下埋植剂。个人和计划生育方案的避孕选择应考虑预期的持续使用情况。

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