Pouwels P J, Frahm J
Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.
Magn Reson Med. 1998 Jan;39(1):53-60. doi: 10.1002/mrm.1910390110.
The regional distribution of brain metabolites was studied in several cortical white and gray matter areas, cerebellum, and thalamus of young adults with use of quantitative single-voxel proton MRS at 2.0 T. Whereas the neuronal compound N-acetylaspartate is distributed homogeneously throughout the brain, N-acetylaspartylglutamate increases caudally and exhibits higher concentrations in white matter than in gray matter. Creatine, myo-inositol, glutamate, and glutamine are less concentrated in cortical white matter than in gray matter. The highest creatine levels are found in cerebellum, parallel to the distribution of creatine kinase and energy-requiring processes in the brain. Also myo-inositol has highest concentrations in the cerebellum. Choline-containing compounds exhibit a marked regional variability with again highest concentrations in cerebellum and lowest levels and a strong caudally decreasing gradient in gray matter. The present findings neither support a metabolic gender difference (except for a 1.3-fold higher myo-inositol level in parietal white matter of female subjects) nor a metabolic hemispheric asymmetry.
利用2.0T定量单体素质子磁共振波谱技术，对年轻成年人的几个皮质白质和灰质区域、小脑及丘脑的脑代谢物区域分布进行了研究。神经元化合物N-乙酰天门冬氨酸在全脑分布均匀，而N-乙酰天门冬氨酰谷氨酸在尾部增加，且在白质中的浓度高于灰质。肌酸、肌醇、谷氨酸和谷氨酰胺在皮质白质中的浓度低于灰质。小脑的肌酸水平最高，这与脑内肌酸激酶的分布和能量需求过程一致。肌醇在小脑中的浓度也最高。含胆碱化合物表现出明显的区域变异性，在小脑中浓度再次最高，在灰质中水平最低且有明显的尾部递减梯度。目前的研究结果既不支持代谢的性别差异（女性受试者顶叶白质中肌醇水平除外，其比男性高1.3倍），也不支持代谢的半球不对称性。
