Ahmadzadeh N, Shingu M, Nobunaga M, Tawara T
Department of Internal Medicine, Kyushu University, Beppu, Japan.
Inflammation. 1991 Dec;15(6):497-503. doi: 10.1007/BF00923346.
Leukotriene B4 (LTB4) was measured in synovial fluid from 20 patients with rheumatoid arthritis and 15 patients with osteoarthritis. The level of LTB4 was significantly higher in synovial fluid from rheumatoid arthritis patients as compared with synovial fluid from osteoarthritis patients. LTB4 levels also significantly correlated with cell numbers, rheumatoid factor, and immune complexes in synovial fluid from rheumatoid arthritis patients. There was an inverse correlation between LTB4 levels and complement components. The high-pressure liquid chromatography peak of immunoreactivity extracted from the synovial fluid occurred at a retention volume identical to that of authentic LTB4. These results suggest that the increased level of this mediator in synovial fluid may contribute to perpetuation of inflammation and tissue destruction in rheumatoid arthritis.
对20例类风湿性关节炎患者和15例骨关节炎患者的滑液进行了白三烯B4（LTB4）检测。与骨关节炎患者的滑液相比，类风湿性关节炎患者滑液中的LTB4水平显著更高。LTB4水平还与类风湿性关节炎患者滑液中的细胞数量、类风湿因子和免疫复合物显著相关。LTB4水平与补体成分呈负相关。从滑液中提取的免疫反应性高压液相色谱峰出现在与 authentic LTB4相同的保留体积处。这些结果表明，滑液中这种介质水平的升高可能有助于类风湿性关节炎中炎症的持续和组织破坏。
