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小鼠中过甲酸、过乙酸和过丙酸吸入毒性的研究。

Study of inhalation toxicity of performic, peracetic and perpropionic acid in mice.

作者信息

Mĕrka V, Urban R

出版信息

J Hyg Epidemiol Microbiol Immunol. 1976;20(1):54-60.

PMID:944215
Abstract

The acute and subacute inhalation toxicity of laboratory performic, peracetic and stabilized aqueous peracetic acid solution. The differences in the toxicity of the studied of the commercial preparation Persteril for mice was studied. Persteril is a 40% peracids were not statistically significant. The histological findings in the lung tissue of intoxicated mice show that the effet of the given peracids is qualitatively the same. Although their toxicity is not very high, in repared inhalation they can induce temporary pathomorphological lesions in the lung parenchyma and have a negative effect on the development of mice in concentrations of about only 70 mg/m3 air. As regards their inhalation toxicity, performic and perpropionic acid have no advantages over peracetic acid for practical use in the air disinfection. The findings show that it is necessary for persons carrying out spatial disinfection with one of the studied peracids to wear an protective mask.

摘要

实验室用过氧甲酸、过氧乙酸及稳定化过氧乙酸水溶液的急性和亚急性吸入毒性。研究了商业制剂Persteril(一种40%的过酸制剂)对小鼠毒性的差异。结果表明,所研究的过酸制剂之间的毒性差异无统计学意义。中毒小鼠肺组织的组织学检查结果显示,所给过酸的作用在性质上是相同的。虽然它们的毒性不是很高,但在吸入条件下,它们在约70毫克/立方米空气浓度时就能在肺实质中诱发暂时性病理形态学损伤,并对小鼠发育产生负面影响。就吸入毒性而言,过氧甲酸和过丙酸在空气消毒实际应用中相对于过氧乙酸并无优势。研究结果表明,使用所研究的过酸之一进行空间消毒的人员有必要佩戴防护口罩。

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