Zigman S, Hare J D
Mol Cell Biochem. 1976 Feb 25;10(3):131-5. doi: 10.1007/BF01731683.
Exposure of dilute aqueous solutions of tryptophan to near UV light (320 to 390 nm) at subsolar levels yields fluorescent photoproducts capable of inhibiting the growth and differentiation of cultured mouse embryonic fibroblasts and fertilized sea urchin eggs. The ability of these cells to incorporate labelled precursors of protein, RNA, and DNA into their respective macromolecules was markedly inhibited by adding tryptophan preirradiated with near UV light to their incubation media. Thus the inhibition of growth and differentiation of these cells seems to result from a depression of their ability to synthesize macromolecules in the presence of the photoproducts.
将色氨酸稀水溶液在接近太阳光照强度下暴露于近紫外光（320至390纳米）会产生荧光光产物，这些产物能够抑制培养的小鼠胚胎成纤维细胞和受精海胆卵的生长与分化。通过向其孵育培养基中添加经近紫外光预辐照的色氨酸，这些细胞将标记的蛋白质、RNA和DNA前体掺入各自大分子中的能力受到显著抑制。因此，这些细胞生长和分化的抑制似乎是由于在光产物存在下它们合成大分子的能力受到抑制所致。
