Ohrnell L O, Brånemark R, Nyman J, Nilsson P, Thomsen P
Institute of Anatomy and Cell Biology, Göteborg University, Sweden.
Scand J Plast Reconstr Surg Hand Surg. 1997 Dec;31(4):281-93. doi: 10.3109/02844319709008974.
The present study reports on the late effects of increasing doses of radiation on the biomechanics of commercially pure titanium implants (fixtures) installed in the proximal tibia in 26 rats. Twelve weeks after various doses (10, 20, 30, and 35 Gy) of irradiation, the fixtures were inserted into rat tibiae, and after another eight weeks these were tested mechanically in vivo. Acute dose dependent skin reactions developed after all doses except 10 Gy, but most subsided within two to three weeks. There was a statistically significant reduction in torsion but the pull-out load was not significantly reduced for single doses up to 30 Gy. Histological analysis showed that bone remodelling was impaired. Shear stresses and shear moduli were estimated for the bone-implant interface and in the surrounding bone tissue. These estimated stresses and moduli were not found to be correlated to the dose of radiation.
本研究报告了递增剂量辐射对26只大鼠胫骨近端植入的商业纯钛种植体（固定装置）生物力学的后期影响。在给予不同剂量（10、20、30和35 Gy）的辐射12周后，将固定装置植入大鼠胫骨，再过8周后对其进行体内力学测试。除10 Gy外，所有剂量照射后均出现急性剂量依赖性皮肤反应，但大多数在两到三周内消退。扭转力有统计学意义的降低，但单剂量达30 Gy时拔出负荷无显著降低。组织学分析表明骨重塑受损。对骨-种植体界面及周围骨组织的剪应力和剪切模量进行了估计。未发现这些估计的应力和模量与辐射剂量相关。
