Olakowski M, Lampe P, Mekle H, Stefański L
Kliniki Chirurgii Przewodu Pokarmowego Slaskiej Akademii Medycznej w Katowicach.
Wiad Lek. 1997;50 Suppl 1 Pt 1:213-7.
In our study we examined the influence of surgical treatment of gallstones on erythrocyte antioxidant system. The investigated group consisted of thirty three (33) women patients 15 were operated laparoscopically and 18-by means of open cholecystectomy. Using proper criteria of classification to the study we obtained 2 similar groups of patients. We compared changes in activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and level of lipid peroxides (MDA) in early period after operation. The study revealed that laparoscopic cholecystectomy causes minor changes in activity of antioxidant enzymes and level of MDA than open cholecystectomy. Laparoscopic method causes less "oxidative stress" in human erythrocytes which suggests its minor traumatic effect than the open method.
在我们的研究中，我们考察了胆结石手术治疗对红细胞抗氧化系统的影响。研究组由33名女性患者组成，其中15例行腹腔镜手术，18例行开腹胆囊切除术。通过适当的分类标准进行研究，我们得到了两组相似的患者。我们比较了术后早期抗氧化酶超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）的活性变化以及脂质过氧化物（MDA）的水平。研究表明，与开腹胆囊切除术相比，腹腔镜胆囊切除术引起的抗氧化酶活性变化和MDA水平变化较小。腹腔镜手术方法对人体红细胞造成的“氧化应激”较小，这表明其创伤性比开腹手术方法小。
