Nagata C, Takatsuka N, Kurisu Y, Shimizu H
Department of Public Health, Gifu University School of Medicine, Gifu 500, Japan.
J Nutr. 1998 Feb;128(2):209-13. doi: 10.1093/jn/128.2.209.
The relationship between soy product intake and serum total cholesterol concentration was examined in 1242 men and 3596 women who participated in an annual health check-up program in Takayama City, Japan, provided by the municipality in 1992. The intake of soy products and various foods and nutrients was assessed by a semiquantitative food-frequency questionnaire. Blood samples were collected from fasting subjects to measure the serum total cholesterol concentration. A significant trend (P for trend = 0. 0001) was observed for decreasing total cholesterol concentration with an increasing intake of soy products in men after controlling for age, smoking status and intake of total energy, total protein and total fat. This negative trend (P for trend = 0.0001) was also noted in women after controlling for age, menopausal status, body mass index and intake of total energy and vitamin C. An additional adjustment for physical activity, coffee and tea consumption, and intake of cholesterol, carbohydrates, fiber and vitamin E did not change the results. These data suggest a role for soy products in human cholesterol homeostasis.
1992年，日本高山市政府开展了年度健康检查项目，对1242名男性和3596名女性进行了大豆制品摄入量与血清总胆固醇浓度之间关系的研究。通过半定量食物频率问卷评估大豆制品及各类食物和营养素的摄入量。从空腹受试者采集血样以测量血清总胆固醇浓度。在控制年龄、吸烟状况以及总能量、总蛋白和总脂肪摄入量后，观察到男性中随着大豆制品摄入量增加，总胆固醇浓度呈显著下降趋势（趋势P值 = 0.0001）。在控制年龄、绝经状态、体重指数以及总能量和维生素C摄入量后，女性中也观察到这种负相关趋势（趋势P值 = 0.0001）。对身体活动、咖啡和茶的摄入量以及胆固醇、碳水化合物、纤维和维生素E摄入量进行进一步调整后，结果未改变。这些数据表明大豆制品在人体胆固醇稳态中发挥作用。
