子宫内膜异位症相关性和不明原因不孕症中的卵巢功能障碍。
Ovarian dysfunction in endometriosis-associated and unexplained infertility.
作者信息
Cahill D J, Wardle P G, Maile L A, Harlow C R, Hull M G
机构信息
Department of Hospital Medicine, University of Bristol, St. Michael's Hospital, England.
出版信息
J Assist Reprod Genet. 1997 Nov;14(10):554-7. doi: 10.1023/a:1022568331845.
Abstract
PURPOSE
The impact of endometriosis and unexplained infertility on follicular function and fertilization of oocytes in cycles totally unperturbed by exogenous gonadotrophins, when compared with controls with tubal damage, were examined.
METHODS
In natural cycles, without any exogenous gonadotropins, endocrine and ultrasonographic studies of follicular maturation in 18 women with minor endometriosis (41 cycles), 15 women with unexplained infertility (31 cycles), and 34 women with tubal damage (88 cycles) were performed.
RESULTS
The endometriosis group had a significantly longer follicular phase (median: 15, 13, and 13 days). Both endometriosis and unexplained infertility had significantly reduced LH concentrations in follicular fluid compared with tubal damage (median: 12.1, 11.5, and 15.9 IU/L, respectively). Endometriosis was associated with a significantly reduced fertilization rate compared with unexplained infertility or tubal damage (46, 65, and 69%, respectively).
CONCLUSIONS
These data show continuing evidence of ovulatory dysfunction leading to reduced fertilization rates in women with minor endometriosis.
摘要
目的
与输卵管损伤的对照组相比，研究子宫内膜异位症和不明原因不孕症在完全未受外源性促性腺激素干扰的周期中对卵泡功能和卵母细胞受精的影响。
方法
在无任何外源性促性腺激素的自然周期中，对18例轻度子宫内膜异位症患者（41个周期）、15例不明原因不孕症患者（31个周期）和34例输卵管损伤患者（88个周期）进行卵泡成熟的内分泌和超声检查。
结果
子宫内膜异位症组的卵泡期明显更长（中位数分别为15天、13天和13天）。与输卵管损伤相比，子宫内膜异位症组和不明原因不孕症组卵泡液中的促黄体生成素（LH）浓度均显著降低（中位数分别为12.1 IU/L、11.5 IU/L和15.9 IU/L）。与不明原因不孕症或输卵管损伤相比，子宫内膜异位症患者的受精率显著降低（分别为46%、65%和69%）。
结论
这些数据持续表明，轻度子宫内膜异位症女性存在排卵功能障碍，导致受精率降低。
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本文引用的文献
1
Pituitary-ovarian dysfunction as a cause for endometriosis-associated and unexplained infertility.垂体-卵巢功能障碍作为子宫内膜异位症相关性不孕和不明原因不孕的一个病因
Hum Reprod. 1995 Dec;10(12):3142-46. doi: 10.1093/oxfordjournals.humrep.a135876.
2
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Hum Reprod. 1996 Mar;11(3):647-50. doi: 10.1093/humrep/11.3.647.
3
Reduced preovulatory granulosa cell steroidogenesis in women with endometriosis.子宫内膜异位症女性排卵前颗粒细胞类固醇生成减少。
J Clin Endocrinol Metab. 1996 Jan;81(1):426-9. doi: 10.1210/jcem.81.1.8550788.
4
Monitoring ovarian follicular development with real-time ultrasound.通过实时超声监测卵泡发育。
Br J Obstet Gynaecol. 1980 Jul;87(7):613-8. doi: 10.1111/j.1471-0528.1980.tb05015.x.
5
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6
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Fertil Steril. 1983 Dec;40(6):755-62. doi: 10.1016/s0015-0282(16)47475-3.
7
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Fertil Steril. 1985 Mar;43(3):351-2. doi: 10.1016/s0015-0282(16)48430-x.
8
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Fertil Steril. 1988 Jan;49(1):47-51. doi: 10.1016/s0015-0282(16)59646-0.
9
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10
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