Armstrong D W, Nair U B
Department of Chemistry, University of Missouri-Rolla, MO 65401, USA.
Electrophoresis. 1997 Nov;18(12-13):2331-42. doi: 10.1002/elps.1150181224.
Macrocyclic antibiotics are the newest class of chiral selector used in capillary electrophoresis (CE) enantioseparations. Two basic types of compounds have proven to produce useful enantioseparations. They are the ansa compounds and the glycopeptides. The ansa compounds best resolve basic or cationic racemates while the glycopeptides best resolve acidic or anionic analytes. The structure and use of these chiral selectors are discussed. The factors affecting separation and the separation mechanism are considered as well.
大环抗生素是毛细管电泳（CE）对映体分离中使用的最新一类手性选择剂。已证明有两种基本类型的化合物可实现有效的对映体分离。它们是ansa化合物和糖肽。ansa化合物最适合分离碱性或阳离子外消旋体，而糖肽最适合分离酸性或阴离子分析物。本文讨论了这些手性选择剂的结构和用途。同时也考虑了影响分离的因素和分离机制。
