Negishi H, Yamada H, Okuyama K, Sagawa T, Makinoda S, Fujimoto S
Department of Obstetrics and Gynecology, Hokkaido University, School of Medicine, Sapporo, Japan.
Int J Gynaecol Obstet. 1995 Apr;49(1):17-20. doi: 10.1016/0020-7292(95)02341-9.
The purpose of this study was to investigate the changes in the level of fetal fibronectin in amniotic fluid during the course of pregnancy.
Amniotic fluid samples were obtained from 74 women whose pregnancies ranged in gestation from 14 to 38 weeks. Fetal fibronectin in amniotic fluid was examined with a sensitive immunoassay using a monoclonal antibody FDC-6 which recognizes a unique epitope (III-CS) of the molecule.
Fetal fibronectin levels in amniotic fluid decreased significantly during pregnancy (r = -0.79, P < 0.0001). The mean levels at less than 20 weeks of gestation were significantly higher than those at 20-29 weeks (P < 0.0001) and at 30 weeks to term (P < 0.0001).
These results must be considered when fetal fibronectin in vaginal fluid is used as an indicator of the rupture of membranes.
本研究旨在探讨孕期羊水中胎儿纤连蛋白水平的变化。
从74名妊娠14至38周的妇女中获取羊水样本。使用识别该分子独特表位（III-CS）的单克隆抗体FDC-6，通过灵敏的免疫测定法检测羊水中的胎儿纤连蛋白。
孕期羊水中胎儿纤连蛋白水平显著下降（r = -0.79，P < 0.0001）。妊娠少于20周时的平均水平显著高于20至29周时（P < 0.0001）以及30周足月时（P < 0.0001）。
当将阴道液中的胎儿纤连蛋白用作胎膜破裂的指标时，必须考虑这些结果。
