Armas-Merino R, Wolff C, Parraguez A, Soto J R
Department de Medicina Occidente, Hospital San Juan de Dios, Universidad de Chile, Santiago.
Rev Med Chil. 1997 Mar;125(3):279-82.
The high prevalence of chronic hepatitis C virus infection in patients with porphyria cutanea tarda, specially in those without family history of the disease, suggests that this could be an acquired disease and one of the most frequent extra hepatic manifestations of hepatitis C virus infection.
To study the excretion of porphyrins and its precursors in cirrhotic patients with and without hepatitis C virus infection.
Eighteen patients with cirrhosis Child-Pough A, eight infected with hepatitis C virus, were studied. Urinary excretion of [symbol see text] aminolevulinic acid, porphobilinogen, coproporphyrins, uroporphyrins and fecal excretion of coproporphyrins and protoporphyrins were measured. Red blood cell protoporphyrin was also measured.
There were no differences in the measured parameters between patients with or without hepatitis C virus infection. No patient had uroporphyrin excretion values over the normal range. Some patients had slight elevations in some parameters, but always below the values observed in porphyrias.
In these group of patients, hepatitis C virus infection of its associated liver disease, do not cause detectable alterations in porphyrin metabolism.
迟发性皮肤卟啉症患者中丙型肝炎病毒感染的高患病率，特别是在那些没有该疾病家族史的患者中，表明这可能是一种后天性疾病，也是丙型肝炎病毒感染最常见的肝外表现之一。
研究丙型肝炎病毒感染和未感染的肝硬化患者中卟啉及其前体的排泄情况。
对18例Child-Pough A级肝硬化患者进行研究，其中8例感染了丙型肝炎病毒。测定了尿中δ-氨基乙酰丙酸、卟胆原、粪卟啉、尿卟啉的排泄量以及粪中粪卟啉和原卟啉的排泄量。还测定了红细胞原卟啉。
丙型肝炎病毒感染患者和未感染患者的测量参数没有差异。没有患者的尿卟啉排泄值超过正常范围。一些患者的某些参数略有升高，但始终低于卟啉症中观察到的值。
在这组患者中，丙型肝炎病毒感染及其相关的肝脏疾病不会导致卟啉代谢出现可检测到的改变。
