• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.

作者信息

Froelich C J, Dixit V M, Yang X

机构信息

Dept of Medicine, Evanston Hospital, Northwestern University, Evanston, IL 60201, USA.

出版信息

Immunol Today. 1998 Jan;19(1):30-6. doi: 10.1016/s0167-5699(97)01184-5.

DOI:10.1016/s0167-5699(97)01184-5
PMID:9465486
Abstract
摘要

相似文献

1
Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.淋巴细胞颗粒介导的凋亡：病毒模拟与致命蛋白酶相关问题
Immunol Today. 1998 Jan;19(1):30-6. doi: 10.1016/s0167-5699(97)01184-5.
2
Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation.细胞毒性T细胞和自然杀伤细胞的杀伤作用：多种颗粒丝氨酸蛋白酶作为DNA片段化的启动因子
Immunol Cell Biol. 1993 Jun;71 ( Pt 3):201-8. doi: 10.1038/icb.1993.22.
3
Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?颗粒酶的穿孔素依赖性核靶向作用：在颗粒胞吐介导的凋亡核事件中起核心作用？
Immunol Cell Biol. 1999 Jun;77(3):206-15. doi: 10.1046/j.1440-1711.1999.00817.x.
4
Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.细胞毒性颗粒介导的细胞凋亡：解析复杂机制。
Curr Opin Immunol. 2003 Oct;15(5):528-32. doi: 10.1016/s0952-7915(03)00111-0.
5
Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.细胞毒性T细胞和自然杀伤细胞诱导的靶细胞凋亡涉及成孔蛋白穿孔素和丝氨酸蛋白酶颗粒酶B之间的协同作用。
Aust N Z J Med. 1995 Dec;25(6):793-9. doi: 10.1111/j.1445-5994.1995.tb02883.x.
6
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.颗粒酶A和颗粒酶B在介导同样表达溶细胞素/穿孔素的大鼠嗜碱性白血病肥大细胞瘤的靶细胞死亡中的协同作用。
J Exp Med. 1995 Mar 1;181(3):1037-46. doi: 10.1084/jem.181.3.1037.
7
How do cytotoxic lymphocytes kill their targets?细胞毒性淋巴细胞是如何杀死其靶标的？
Curr Opin Immunol. 1998 Oct;10(5):581-7. doi: 10.1016/s0952-7915(98)80227-6.
8
Fas and other cell death signaling pathways.Fas及其他细胞死亡信号通路。
Semin Immunol. 1997 Apr;9(2):93-107. doi: 10.1006/smim.1997.0062.
9
Hypothesis: cytotoxic lymphocyte granule serine proteases activate target cell endonucleases to trigger apoptosis.假设：细胞毒性淋巴细胞颗粒丝氨酸蛋白酶激活靶细胞核酸内切酶以触发细胞凋亡。
Clin Exp Pharmacol Physiol. 1994 Jan;21(1):67-70. doi: 10.1111/j.1440-1681.1994.tb02438.x.
10
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection.前沿：颗粒酶A和B对于穿孔素介导的肿瘤排斥反应并非必不可少。
J Immunol. 2003 Jul 15;171(2):515-8. doi: 10.4049/jimmunol.171.2.515.

引用本文的文献

1
Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential.海洋源天然产物治疗结直肠癌和胰腺癌的作用机制及潜力
Int J Mol Sci. 2022 Jul 21;23(14):8048. doi: 10.3390/ijms23148048.
2
Oxidative and Non-Oxidative Antimicrobial Activities of the Granzymes.颗粒酶的氧化和非氧化抗菌活性。
Front Immunol. 2021 Oct 11;12:750512. doi: 10.3389/fimmu.2021.750512. eCollection 2021.
3
RNA Viruses: ROS-Mediated Cell Death.RNA病毒：活性氧介导的细胞死亡
Int J Cell Biol. 2014;2014:467452. doi: 10.1155/2014/467452. Epub 2014 May 8.
4
Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.CD8+ 细胞毒性 T 淋巴细胞中细胞裂解颗粒胞吐作用的成像揭示了一种完全融合的改良形式。
Cell Immunol. 2011;271(2):267-79. doi: 10.1016/j.cellimm.2011.07.004. Epub 2011 Jul 24.
5
Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targets.结外NK/T细胞淋巴瘤：迈向临床分子靶点的鉴定
J Biomed Biotechnol. 2011;2011:790871. doi: 10.1155/2011/790871. Epub 2011 Apr 20.
6
Intratumour T cells, their activation status and survival in gastric carcinomas characterised for microsatellite instability and Epstein-Barr virus infection.针对微卫星不稳定性和爱泼斯坦-巴尔病毒感染特征的胃癌中的肿瘤内T细胞、其激活状态和存活情况。
Virchows Arch. 2006 Mar;448(3):344-53. doi: 10.1007/s00428-005-0066-4. Epub 2005 Oct 27.
7
Apoptosis induction by interleukin-2-activated cytotoxic lymphocytes in a squamous cell carcinoma cell line and Daudi cells - involvement of reactive oxygen species-dependent cytochrome c and reactive oxygen species-independent apoptosis-inducing factors.白细胞介素-2激活的细胞毒性淋巴细胞在鳞状细胞癌细胞系和Daudi细胞中诱导凋亡——活性氧依赖性细胞色素c和活性氧非依赖性凋亡诱导因子的参与
Immunology. 2003 Oct;110(2):217-24. doi: 10.1046/j.1365-2567.2003.01703.x.
8
Endocytosing the death sentence.内吞死刑判决。
J Cell Biol. 2003 Jan 20;160(2):155-6. doi: 10.1083/jcb.200212143. Epub 2003 Jan 21.
9
Kinase inhibitors in cancer therapy: a look ahead.癌症治疗中的激酶抑制剂：展望未来。
Drugs. 2000 Mar;59(3):435-76. doi: 10.2165/00003495-200059030-00004.
10
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.细菌毒素介导颗粒酶B的胞质递送：有证据表明，除形成跨膜孔道外，内体破坏也是穿孔素的一项重要功能。
Mol Cell Biol. 1999 Dec;19(12):8604-15. doi: 10.1128/MCB.19.12.8604.