Harsten A, Gillberg L, Håkansson L, Olsson M
Department of Anaesthesiology, Central Hospital, Kristianstad, Sweden.
Eur J Anaesthesiol. 1997 Nov;14(6):642-5. doi: 10.1046/j.1365-2346.1994.00212.x.
Epidural analgesia for pain relief during labour has certain disadvantages including slow onset. However, intrathecal sufentanil provides rapid onset and well-controlled analgesia lasting 1-4 h. The aim of this study was to compare the analgesia and the side effects of intrathecal sufentanil with epidural bupivacaine during labour. In a randomized, double-blind and controlled trial 58 parturient women requesting analgesia during labour were studied. The patients received either intrathecal sufentanil 10 micrograms and epidural saline, or intrathecal saline and epidural bupivacaine 20 mg. Visual analogue scores (VAS) for pain, blood pressure, heart rate, respiratory rate, level of sedation and the incidence of pruritus and nausea were recorded. Pain scores were significantly lower between 5 and 90 min after injection in patients receiving intrathecal sufentanil. Pruritus was significantly more frequent among those receiving intrathecal sufentanil. The rapid onset and effective analgesia of intrathecal sufentanil may in certain situations be advantageous.
分娩期间用于缓解疼痛的硬膜外镇痛有一些缺点，包括起效缓慢。然而，鞘内注射舒芬太尼起效迅速，镇痛效果良好，持续时间为1 - 4小时。本研究的目的是比较分娩期间鞘内注射舒芬太尼与硬膜外注射布比卡因的镇痛效果及副作用。在一项随机、双盲对照试验中，对58名分娩期间要求镇痛的产妇进行了研究。患者分别接受鞘内注射10微克舒芬太尼加硬膜外注射生理盐水，或鞘内注射生理盐水加硬膜外注射20毫克布比卡因。记录疼痛的视觉模拟评分（VAS）、血压、心率、呼吸频率、镇静程度以及瘙痒和恶心的发生率。接受鞘内注射舒芬太尼的患者在注射后5至90分钟内疼痛评分显著更低。接受鞘内注射舒芬太尼的患者中瘙痒更为常见。鞘内注射舒芬太尼起效迅速且镇痛效果良好，在某些情况下可能具有优势。
