Curran D, Fossa S, Aaronson N, Kiebert G, Keuppens F, Hall R
Quality of Life Unit, EORTC Data Center, Brussels, Belgium.
Eur J Cancer. 1997 Oct;33(11):1809-14. doi: 10.1016/s0959-8049(97)00187-1.
Quality of life (QoL) is now commonly studied in prostate cancer. However, little is known about the appropriateness of the various QoL instruments in this group of patients. The purpose of this work was to study the baseline QoL assessment of patients with prostate cancer who were randomised into three EORTC phase III studies. The three trials included locoregional prostate cancer patients, poor prognosis metastatic patients and hormone resistance patients, respectively. In the three trials, patients were asked to complete a questionnaire assessing their physical and psychosocial functioning and their symptom levels. These questionnaires included questions from the EORTC QLQ-C30 (version 1): the physical functioning, role functioning, global health/QoL scales and a single pain item. The psychometric properties of the scales were assessed and an analysis was performed to investigate if differences existed in the scale scores between the three groups of patients, 638 baseline questionnaires were available for patients entered into the three trials. The Gutman coefficients of reproducibility and scalability were 0.94 and 0.71, respectively, for the physical functioning scale and 0.97 and 0.90, respectively, for the role functioning scale. The Cronbach's alpha reliability coefficients were 0.68, 0.48 and 0.90 for the physical functioning, role functioning and global health/QoL scales, respectively. The four scales were able to distinguish clearly between the patient populations under study. The physical functioning, role functioning, global health/QoL scales and the single pain item scale from the EORTC QLQ-C30 (version 1) are valid measures when used in the setting of prostate cancer.
生活质量（QoL）如今在前列腺癌研究中已较为常见。然而，对于这组患者中各种生活质量评估工具的适用性却知之甚少。本研究的目的是对随机纳入三项欧洲癌症研究与治疗组织（EORTC）III期研究的前列腺癌患者进行基线生活质量评估。这三项试验分别纳入了局部区域性前列腺癌患者、预后较差的转移性患者和激素抵抗性患者。在这三项试验中，患者被要求完成一份问卷，以评估其身体和心理社会功能以及症状水平。这些问卷包括来自EORTC QLQ - C30（第1版）的问题：身体功能、角色功能、总体健康/生活质量量表以及一个单一的疼痛项目。对这些量表的心理测量特性进行了评估，并进行了分析以调查三组患者之间量表得分是否存在差异。共有638份基线问卷可供参与这三项试验的患者使用。身体功能量表的古特曼再现性系数和可扩展性系数分别为0.94和0.71，角色功能量表的分别为0.97和0.90。身体功能、角色功能和总体健康/生活质量量表的克朗巴赫α信度系数分别为0.68、0.48和0.90。这四个量表能够清晰地区分所研究的患者群体。当用于前列腺癌患者时，EORTC QLQ - C30（第1版）中的身体功能、角色功能、总体健康/生活质量量表以及单一疼痛项目量表是有效的测量工具。
