用于诊断急性狂犬病脑炎的角膜印片试验。
Corneal impression test for the diagnosis of acute rabies encephalitis.
作者信息
Zaidman G W, Billingsley A
机构信息
New York Medical College, Westchester County Medical Center, Valhalla 10595, USA.
出版信息
Ophthalmology. 1998 Feb;105(2):249-51. doi: 10.1016/s0161-6420(98)92860-3.
PURPOSE
This study aimed to alert ophthalmologists as to their role in the diagnosis of rabies.
METHODS
A 13-year-old girl was admitted with acute encephalitis of unknown etiology. Bacterial and viral cultures and test results for Lyme disease and tuberculosis were negative. Initial cerebrospinal fluid, serum, skin, and saliva specimens were negative for rabies. A corneal impression test was performed.
RESULTS
Immunofluorescent antibody staining of the epithelial cells on the corneal impression test was positive for rabies. Subsequently, the diagnosis was confirmed by serum serologic analysis and saliva testing.
CONCLUSION
Ophthalmologists can assist in the diagnosis of rabies by using the corneal impression test. Corneal smears should be part of the routine antemortem work-up for presumptive rabies.
目的
本研究旨在提醒眼科医生注意他们在狂犬病诊断中的作用。
方法
一名13岁女孩因病因不明的急性脑炎入院。莱姆病和结核病的细菌及病毒培养以及检测结果均为阴性。最初的脑脊液、血清、皮肤和唾液标本狂犬病检测均为阴性。进行了角膜印片试验。
结果
角膜印片试验上皮细胞的免疫荧光抗体染色狂犬病呈阳性。随后，血清学分析和唾液检测确诊了该诊断。
结论
眼科医生可通过角膜印片试验协助狂犬病的诊断。角膜涂片应作为疑似狂犬病生前常规检查的一部分。
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