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[静脉自控镇痛(PCA)在术后疼痛治疗中的原理与临床应用]

[Intravenous patient-controlled analgesia (PCA) in the treatment of postoperative pain: rationale and clinical application].

作者信息

Finco G, Polati E, Gottin L, Bartoloni A, Milan B, Zanoni L, Valle L

机构信息

Istituto di Anestesiologia e Rianimazione, Centro di Terapia del Dolore, Università degli Studi, Verona.

出版信息

Chir Ital. 1995;47(6):20-5.

PMID:9480189
Abstract

The clinical use of the patient-controlled analgesia (PCA) represents a further improvement in the treatment of post-operative pain. In this way in success due to inadequate protocols, unpredictability of the drug absorption and variability of the response to one drug or to the same pain patterns between patients can be avoided. This technique allows the patient himself to control the pain without depending upon nurses or physicians for the administration of analgesic drugs. Although the PCA is in use since several years, there are still some unresolved problems which are considered in this paper.

摘要

患者自控镇痛(PCA)的临床应用代表了术后疼痛治疗的进一步改进。通过这种方式,可以避免因方案不完善、药物吸收不可预测以及患者对一种药物或相同疼痛模式的反应存在差异而导致的治疗失败。该技术使患者能够自行控制疼痛,而无需依赖护士或医生来给予镇痛药。尽管PCA已经使用了数年,但本文仍将探讨一些尚未解决的问题。

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引用本文的文献

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The role of the opioid receptor-like (ORL1) receptor in motor stimulatory and rewarding actions of buprenorphine and morphine.阿片样物质受体样(ORL1)受体在丁丙诺啡和吗啡的运动刺激及奖赏作用中的角色。
Neuroscience. 2008 Aug 26;155(3):597-602. doi: 10.1016/j.neuroscience.2008.06.027. Epub 2008 Jun 19.
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Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system.
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Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.丁丙诺啡诱导的镇痛作用由μ-阿片受体介导,并因阿片受体样受体的同时激活而减弱。
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