De Moreno J E, Moreno V J, Brenner R R
Lipids. 1976 Jul;11(7):561-6. doi: 10.1007/BF02532902.
The fate of labeled linoleic, alpha-linolenic, and higher homologs of alpha-linolenic acid administered to the yellow clam, Mesodesma mactroides, was investigated. It was found that the clam incorporated the acids dissolved in sea water and converted 18:2 (n-6) into 20:2 (n-6) and 18:3 (n-3) into 18:4 (n-3) and 20:3 (n-3). The addition of casein hydrolysate to the sea water increased the desaturation capacity of the calm and allowed the conversion of 18:2 (n-6) into 18:3 (n-6) to be demonstrated. An enhanced desaturation of 18:3 (n-3) into 18:4 (n-3) was also demonstrated. After 12 hr admininistration of the acid, no radioactivity was found in arachidonic, 20:5 (n-3), or 22:6 (n-3). Feeding the clams a culture of Phaeodactylun tricornutum previously incubated with 1-14C-alph-linolenic acid demonstrated that all the homologs of the alpha-linolenic series were found in the clam without any important changes. Six hour administration of labled linolenic acid resulted in the incorporation of the acid into diglycerides and phospholipids.
研究了给黄斑蛤蜊（Mesodesma mactroides）投喂标记的亚油酸、α-亚麻酸以及α-亚麻酸的高级同系物后的命运。发现蛤蜊吸收了溶解在海水中的这些酸，并将18:2（n-6）转化为20:2（n-6），将18:3（n-3）转化为18:4（n-3）和20:3（n-3）。向海水中添加酪蛋白水解物可提高蛤蜊的去饱和能力，并能证明18:2（n-6）可转化为18:3（n-6）。还证明了18:3（n-3）向18:4（n-3）的去饱和增强。在投喂酸12小时后，在花生四烯酸、20:5（n-3）或22:6（n-3）中未发现放射性。给蛤蜊投喂预先用1-14C-α-亚麻酸培养的三角褐指藻，结果表明在蛤蜊中发现了α-亚麻酸系列的所有同系物，且没有任何重要变化。投喂标记的亚麻酸6小时后，该酸被并入甘油二酯和磷脂中。
