DeVengencie J, Ng M C, Ford P, Iacopino A M
Department of Restorative Sciences, Baylor University College of Dentistry, Dallas, Texas, USA.
Int J Prosthodont. 1997 Jan-Feb;10(1):61-72.
The ideal denture adhesive demonstrates a neutral or slightly basic pH, minimal toxicity to the oral mucosa, and satisfactory adhesive bond strength for 12 to 16 hours. Three brands of commercially available denture adhesives (Fixodent Fresh, Procter and Gamble, Cincinnati, OH; Super Poli Grip, Block Drug, Jersey City, NJ; and Super Wernet's, Block Drug, Jersey City, NJ), and a complex mannose carbohydrate (Acemannan, Carrington Laboratories, Irving, TX) were evaluated in vitro to determine significant differences in pH, cytotoxicity, and adhesive bond strength. Super Poli Grip and Super Wernet's remained above the critical pH for hydroxyapatite (pH 6.5) throughout the study, while Acemannan and Fixodent Fresh did not. Fixodent Fresh exhibited significant cytotoxicity to human gingival fibroblasts. Acemannan demonstrated significantly greater overall mean adhesive bond strength in both dry and simulated oral conditions. The generally favorable in vitro performance of the Acemannan material compared to commercially available denture adhesive formulations indicates that complex carbohydrates may be efficacious denture adhesives.
理想的义齿黏附剂应具有中性或略呈碱性的pH值，对口腔黏膜的毒性最小，且在12至16小时内具有令人满意的黏附强度。对三种市售义齿黏附剂品牌（固齿健清新型，宝洁公司，俄亥俄州辛辛那提市；超强固齿乐，布洛克制药公司，新泽西州泽西城；以及超级韦内特，布洛克制药公司，新泽西州泽西城）和一种复合甘露糖碳水化合物（乙酰甘露聚糖，卡灵顿实验室，得克萨斯州欧文市）进行了体外评估，以确定它们在pH值、细胞毒性和黏附强度方面的显著差异。在整个研究过程中，超强固齿乐和超级韦内特的pH值始终高于羟基磷灰石的临界pH值（pH 6.5），而乙酰甘露聚糖和固齿健清新型则没有。固齿健清新型对人牙龈成纤维细胞表现出显著的细胞毒性。在干燥和模拟口腔条件下，乙酰甘露聚糖的总体平均黏附强度均显著更高。与市售义齿黏附剂配方相比，乙酰甘露聚糖材料总体上良好的体外性能表明，复合碳水化合物可能是有效的义齿黏附剂。
