Tiberti C, Sabe L, Kuzis G, García Cuerva A, Leiguarda R, Starkstein S E
Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
Neurology. 1998 Feb;50(2):546-8. doi: 10.1212/wnl.50.2.546.
We examined the prevalence of the catastrophic reaction (CR) in 146 patients with Alzheimer's disease. Sixteen percent showed a CR during the neuropsychological evaluation. A factor analysis of the CR scale demonstrated an anxious/angry factor that was significantly associated with higher irritability scores and a longer duration of illness, as well as a depressive factor that was significantly associated with more severe cognitive impairments and older age.
我们调查了146例阿尔茨海默病患者中灾难性反应（CR）的发生率。16%的患者在神经心理学评估期间出现了CR。对CR量表进行的因素分析显示，一个焦虑/愤怒因素与更高的易怒得分和更长的病程显著相关，以及一个抑郁因素与更严重的认知障碍和更高年龄显著相关。
