血清瘦素浓度与青春期发育的关系。
Serum leptin concentrations in relation to pubertal development.
作者信息
Carlsson B, Ankarberg C, Rosberg S, Norjavaara E, Albertsson-Wikland K, Carlsson L M
机构信息
Department of Internal Medicine, Sahlgrenska University Hospital, University of Gothenburg, Sweden.
出版信息
Arch Dis Child. 1997 Nov;77(5):396-400. doi: 10.1136/adc.77.5.396.
OBJECTIVES
The amount of adipose tissue influences pubertal development and fertility in girls. A candidate for mediating this is the hormone leptin, derived from adipocytes. This work was carried out to determine whether the leptin concentration in serum is regulated during pubertal development.
SUBJECTS AND METHODS
Serum concentrations of leptin were determined by radioimmunoassay in a sample of 252 healthy children representing all pubertal stages.
RESULTS
Serum leptin concentrations correlated directly with age (r = 0.53), body mass index (BMI) (r = 0.71), and weight for height SD score (r = 0.44) in girls and with BMI (r = 0.33) and weight for height SD score in boys (r = 0.36). Leptin concentrations increased with pubertal development in girls, resulting in significantly higher concentrations at pubertal stages 4 and 5 than at the prepubertal stage, whereas there was no change in the boys.
CONCLUSIONS
Serum leptin concentrations increased during pubertal development in the girls, but remained constant in the boys. Whether the increase in serum leptin concentrations in girls is of importance for, or a consequence of, pubertal development is still to be determined.
目的
脂肪组织的量会影响女孩的青春期发育和生育能力。一种可能介导此作用的物质是源自脂肪细胞的瘦素。开展这项研究是为了确定血清瘦素浓度在青春期发育过程中是否受到调节。
对象与方法
采用放射免疫分析法测定了252名代表所有青春期阶段的健康儿童样本中的血清瘦素浓度。
结果
女孩血清瘦素浓度与年龄（r = 0.53）、体重指数（BMI）（r = 0.71）以及身高标准差体重评分（r = 0.44）直接相关，男孩血清瘦素浓度与BMI（r = 0.33）以及身高标准差体重评分（r = 0.36）直接相关。女孩的瘦素浓度随着青春期发育而升高，导致青春期4期和5期的浓度显著高于青春期前阶段，而男孩则无变化。
结论
女孩青春期发育期间血清瘦素浓度升高，但男孩保持不变。女孩血清瘦素浓度升高对青春期发育是否重要或是否是青春期发育的结果仍有待确定。
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