冷冻治疗后类前列腺素炎症反应的实验性抑制
Experimental inhibition of prostaglandin-like inflammatory response after cryotherapy.
作者信息
Chavis R M, Vygantas C M, Vygantas A
出版信息
Am J Ophthalmol. 1976 Aug;82(2):310-2. doi: 10.1016/0002-9394(76)90439-6.
To determine the effect of aspirin as an inhibitor of the prostaglandin-induced inflammatory reaction that follows cryotherapy, 12 rabbits were pretreated with aspirin and 12 were controls. The aspirin-pretreated animals showed less inflammatory reaction after cryotherapy and significantly less protein in the aqueous humor than did the control animals (P less than .01). We believe that the conjunctival hyperemia and chemosis, and the increase in protein concentrations in the aqueous humor that follow cryotherapy, are prostaglandin-related, because pretreatment with aspirin inhibited these phenomena.
为了确定阿司匹林作为前列腺素诱导的冷冻疗法后炎症反应抑制剂的效果，12只兔子用阿司匹林进行预处理，12只作为对照。与对照动物相比，经阿司匹林预处理的动物在冷冻疗法后炎症反应较轻，房水中的蛋白质明显较少（P小于0.01）。我们认为，冷冻疗法后出现的结膜充血、水肿以及房水中蛋白质浓度的增加与前列腺素有关，因为用阿司匹林预处理可抑制这些现象。
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