以色列南部肠球菌血流分离株中抗菌药物耐药性患病率迅速上升。

Rapid increase in the prevalence of antimicrobial drug resistance among enterococcal blood isolates in southern Israel.

作者信息

Marcus N, Peled N, Yagupsky P

机构信息

Clinical Microbiology Laboratories, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

出版信息

Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):913-5. doi: 10.1007/BF01700558.

DOI:10.1007/BF01700558

PMID:9495672

Abstract

A prospective surveillance was conducted to monitor the prevalence and dynamics of antimicrobial resistance among enterococci isolated from blood cultures in southern Israel. A total of 242 organisms isolated between 1993 and 1996 were studied. The prevalence of Enterococcus faecalis significantly decreased during the study period, whereas that of Enterococcus faecium doubled. Antimicrobial drug resistance increased steadily among Enterococcus faecium isolates: resistance to ampicillin increased from 19% in 1993-1994 to 53% in 1995, and to 67% in 1996 (p = 0.005); during the same period, resistance to vancomycin increased from 0% to 20%, and to 50% (p = 0.002), and combined resistance to ampicillin and vancomycin and high-level resistance to gentamicin from 0% to 20% and to 38% (p < 0.02).

摘要

进行了一项前瞻性监测，以监测以色列南部从血培养中分离出的肠球菌的抗菌药物耐药性流行情况和动态变化。对1993年至1996年间分离出的总共242株菌株进行了研究。在研究期间，粪肠球菌的流行率显著下降，而屎肠球菌的流行率则翻了一番。屎肠球菌分离株的抗菌药物耐药性稳步上升：对氨苄西林的耐药率从1993 - 1994年的19%增至1995年的53%，并在1996年达到67%（p = 0.005）；在同一时期，对万古霉素的耐药率从0%增至20%，并在1996年达到50%（p = 0.002），对氨苄西林和万古霉素的联合耐药率以及对庆大霉素的高水平耐药率从0%增至20%，并在1996年达到38%（p < 0.02）。