Rothenbacher D, Bode G, Adler G, Brenner H
Department of Epidemiology, University of Ulm, Germany.
J Clin Epidemiol. 1998 Mar;51(3):267-71. doi: 10.1016/s0895-4356(97)00282-5.
We investigated the association of commonly prescribed antibiotics with the prevalence of current Helicobacter pylori infection among children. All children who were screened in 1996 for school fitness by physicians of the Public Health Service in Ulm, a city in the south of Germany, were invited to participate in the study. Infection status was determined by 13C-urea breath test. In addition, the parents of the children were asked to fill out a standardized questionnaire. Nine hundred forty-five out of the 1201 eligible children participated in the study (response rate = 79%). The children were aged 5 to 8 years. Seventeen children who were receiving antibiotics at the day of the breath test were excluded from the analysis. Overall, for 683 children (73.6%) a prior usage of antibiotics was reported. Prevalence of H. pylori infection was significantly lower in children with reported antibiotic usage (odds ratio = 0.46; 95% CI, 0.27-0.76 after adjustment for confounders). Our results suggest that information on prior usage of antibiotics should always be considered in studies evaluating prevalence and risk factors of H. pylori infection in children.
我们研究了常用抗生素与儿童当前幽门螺杆菌感染率之间的关联。1996年，德国南部城市乌尔姆的公共卫生服务机构的医生对所有接受学校健康筛查的儿童进行了邀请，邀请他们参与这项研究。通过¹³C - 尿素呼气试验确定感染状况。此外，还要求儿童的父母填写一份标准化问卷。1201名符合条件的儿童中有945名参与了研究（应答率 = 79%）。这些儿童年龄在5至8岁之间。在呼气试验当天正在接受抗生素治疗的17名儿童被排除在分析之外。总体而言，683名儿童（73.6%）报告曾使用过抗生素。报告使用过抗生素的儿童中，幽门螺杆菌感染率显著较低（调整混杂因素后，比值比 = 0.46；95%置信区间，0.27 - 0.76）。我们的结果表明，在评估儿童幽门螺杆菌感染率和危险因素的研究中，应始终考虑抗生素既往使用情况的信息。
