Brosens I, Deprest J, Dal Cin P, Van den Berghe H
University Hospital Gasthuisberg, Leuven, Belgium.
Fertil Steril. 1998 Feb;69(2):232-5. doi: 10.1016/s0015-0282(97)00472-x.
To investigate the clinical characteristics of uterine myomas with cytogenetic rearrangements.
Comparative study of myomas with normal and abnormal karyotype.
University hospital.
Premenopausal, GnRH-agonist (GnRH-a) treated and menopausal patients.
Myomectomy or hysterectomy.
Karyotype analysis and clinical characteristics.
Clonal abnormalities occurred in 29% of uterine myomas but were not related to the age of the patient or, in untreated menopausal patients, to the size of the myoma. In GnRH-a treated and menopausal women, 48% of the myomas larger than 4 cm were associated with clonal abnormalities. Submucous myomas had significantly fewer clonal abnormalities (12%) than subserosal (29%) or intramural myomas (35%).
The data support the hypothesis that cytogenetic rearrangements in uterine myomas are associated with loss of steroid hormones dependency and alter the growth potential of the tumor.
探讨具有细胞遗传学重排的子宫肌瘤的临床特征。
对核型正常和异常的肌瘤进行对比研究。
大学医院。
绝经前、接受促性腺激素释放激素激动剂（GnRH-a）治疗的患者以及绝经后患者。
肌瘤切除术或子宫切除术。
核型分析和临床特征。
29%的子宫肌瘤存在克隆性异常，但这与患者年龄无关，在未接受治疗的绝经后患者中，也与肌瘤大小无关。在接受GnRH-a治疗的绝经后女性中，4厘米以上的肌瘤有48%存在克隆性异常。黏膜下肌瘤的克隆性异常（12%）明显少于浆膜下肌瘤（29%）或肌壁间肌瘤（35%）。
数据支持以下假设，即子宫肌瘤的细胞遗传学重排与类固醇激素依赖性丧失有关，并改变了肿瘤的生长潜能。
